Research in the Graveley lab is primarily focused on the regulation of alternative splicing and small RNA mediated gene regulation. These are fascinating and extraordinarily important mechanisms by which genes can be regulated. Our long-term goals are to understand how these processes are regulated at a mechanistic level and to understand the logic of these processes in significant biological settings. To achieve these goals, we strive to think outside the box to creatively attack the problems being addressed using a wide variety of approaches that include biochemistry, genetics, imaging, deep sequencing, large-scale RNAi screening and bioinformatics.
McManus, C.J., Coolon, J.D., Eipper-Mains, J., Wittkopp, P.J. and Graveley, B.R. (2014) Evolution of Splicing Regulatory networks in Drosophila. Genome Research, doi:10.1101/gr.161521.113. PubMed
Miura SK, Martins A, Zhang KX, Graveley BR, and Zipursky SL. (2013) Probabilistic Splicing of Dscam1 Establishes Identity at the Level of Single Neurons. Cell 155:1166-1177 PubMed
Plocik AM and Graveley BR. (2013) New Insights from Existing Sequence Data: Generating Breakthroughs without a Pipette. Molecular Cell 49:605-617 PubMed
Hale CR, Majumdar S, Elmore J, Pfister N, Compton M, Olson S, Resch AM, Glover CVCIII, Graveley BR, Terns RM, Terns MP. (2012) Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs. Mol. Cell, 45:292-302 PubMed
Graveley et al. (2011) The developmental transcriptome of Drosophila melanogaster. Nature. 471:473-9. PubMed
McManus CJ, Duff MO, Eipper-Mains J, Graveley BR. (2010) Global analysis of trans-splicing in Drosophila. Proc Natl Acad Sci U S A 107:12975-9.PubMed
Brent Graveley is elected to the Connecticut Academy of Science and Engineering.
The Graveley lab is selected to participate in the Oxford Nanopore MinIONTM Access Programme.
Congratulations to Sandy Garrett for being awarded an NIH Postdoctoral Fellowship.
New paper on splicing regulatory evolution in Drosophila in collaboration with the Wittkopp and McManus labs published in Genome Research. [Online at Genome Research]
Congratulations to Mohan Bolisetty for being awarded an American Heart Association Postdoctoral Fellowship.
Our collaboration with Larry Zipursky's lab on Probabilistic Splicing of Dscam in single neurons is published in Cell. PubMed
Work in our lab is funded by R01 grants from NIGMS and a U54 ENCODE grant from NHGRI.