Overview
Research in the Graveley lab is primarily focused on the regulation of alternative splicing and small RNA mediated gene regulation. These are fascinating and extraordinarily important mechanisms by which genes can be regulated. Our long-term goals are to understand how these processes are regulated at a mechanistic level and to understand the logic of these processes in significant biological settings. To achieve these goals, we strive to think outside the box to creatively attack the problems being addressed using a wide variety of approaches that include biochemistry, genetics, imaging, deep sequencing, large-scale RNAi screening and bioinformatics.
Featured Publications
Plocik AM and Graveley BR. (2013) New Insights from Existing Sequence Data: Generating Breakthroughs without a Pipette. Molecular Cell 49:605-617 PubMed
Smibert P, Miura P, Westholm JO, Shenker S, May G, Duff MO, Zhang D, Eads BD, Carlson J, Brown JB, Eisman RC, Andrews J, Kaufman T, Cherbas P, Celniker SE, Graveley BR, Lai EC. (2012) Global Patterns of Tissue-Specific Alternative Polyadenylation in Drosophila. Cell Reports, 1:277-289. PubMed
Hale CR, Majumdar S, Elmore J, Pfister N, Compton M, Olson S, Resch AM, Glover CVCIII, Graveley BR, Terns RM, Terns MP. (2012) Essential features and rational design of CRISPR RNAs that function with the Cas RAMP mosdule complex to cleave RNAs. Mol. Cell, 45:292-302 PubMed
Graveley et al. (2011) The developmental transcriptome of Drosophila melanogaster. Nature. 471:473-9. PubMed
McManus CJ, Duff MO, Eipper-Mains J, Graveley BR. (2010) Global analysis of trans-splicing in Drosophila. Proc Natl Acad Sci U S A 107:12975-9.PubMed
Recent News
4/25/13
On the 30th Anniversary of the publication of the double helix by Watson and Crick Brent and other members of the editorial board of Genome Biology reflect on the most significant discoveries in the field since then PDF.
3/18/13
Congratulations to Alex Plocik for the publication of two review articles in Cell and Molecular Cell.
3/18/13
Congratulations to Sara Olson for her publication in RNA Biology on CRISPR RNAs, which was a collaboration with Mike and Becky Terns labs.
2/15/13
Welcome to the newest member of the lab, Postdoctoral fellow Sandy Garrett.
2/15/13
Congratulations to Alex Plocik for being awarded an NIH Postdoctoral Fellowship.
10/5/12
Welcome to the newest members of the lab, Postdoctoral fellow Mohan Bolisetty and Research Associate Xintao Wei.
9/24/12
Brent Graveley, in collaboration with Chris Burge, Xiang-Dong Fu, and Gene Yeo, was awarded a $9.3 million, 4 year grant to identify functional RNA elements in the human genome as part of the next phase of the ENCODE project NHGRI Press Release
Funding
Work in our lab is funded by R01 grants from NIGMS and a U54 ENCODE grant from NHGRI.